Non exophthalmic Graves'
Conditions
Interventions
1.History of diagnosis of Graves'
disease
2.History of laboratory investigation that shown low TSH level at least 1 time after diagnosed as Graves'
disease
3.Had thyroid function test : T3 or FT3 and T4 or FT4 level within 1 week and results shown high level of T3 or FT3 or T4 or FT4 level,1.History of diagnosis of Graves'
disease
3.Had thyroid function test : T3 or FT3 and T4 or FT4 level within 1 week and results of T3 or FT3 and T4 or FT4 level are all within normal limit,1.No symptoms of thyroid disease and no previ
Other,Other,Other
Graves'
disease with biochemical hyperthyroid,Graves'
disease with biochemical euthyroid,Control group
Sponsors
Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol university
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Group 1 : Graves' disease with biochemical of hyperthyroid 1.History of diagnosis of Graves' disease 2.History of laboratory investigation that shown low TSH level at least 1 time after diagnosed as Graves' disease 3.Had thyroid function test : T3 or FT3 and T4 or FT4 level within 1 week and results shown high level of T3 or FT3 or T4 or FT4 level Group2 : Graves' disease with biochemical of euthyroid 1.History of diagnosis of Graves' disease 2.History of laboratory investigation that shown low TSH level at least 1 time after diagnosed as Graves' disease 3.Had thyroid function test : T3 or FT3 and T4 or FT4 level within 1 week and results of T3 or FT3 and T4 or FT4 level are all within normal limit Group3 : Control group 1.No symptoms of thyroid disease and no previous diagnosis of thyroid disease 2.No family history of thyroid disease
Exclusion criteria
Exclusion criteria: 1.Age 65 year or female age > 55 year 2.Proptosis from Hertel exopthalmometer 2.1 Enlargement of eye >20mm or 2.2 Different size of 2 eyes > 2mm 3.Previous diagnosed as dry eye 4.Previous diagnosed as allergic conjunctivitis 5.Previous diagnosed as Sjogren syndrome 6.Previous diagnosed as glaucoma and used anti-glaucomatic drug 7.Eye infection or red eye 8.History of lid, conjunctiva, pterygium or ocular surgery 9.History of eye prosthesis 10.History of contact lens wear 1 month before 11.History of HIV or autoimmune deficiency disease 12.History of heapatitis C infection and receive anti-viral treatment 13.Previous diagnosed as rheumatoid arthritis 14.History of iodine131 ablation (I-131) 15.History of use antihistamine within 2 weeks 16.Eye examination reveals lid lag or lid retraction in one or both eyes 17.Vulnerable subject e.g. Inpatient case, emergency case, immigrant, pregnancy etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare ocular symptom score 15/5/2017-31/1/2019 Questionaires,Compare quality of tear 15/5/2017-31/1/2019 Fluorescein tear break up time test,Compare blinking (complete/incomplete) 15/5/2017-31/1/2019 observation eyes,Compare meibomian gland dysfunction 15/5/2017-31/1/2019 Meibomian gland grading score,Compare lid margin inflammation 15/5/2017-31/1/2019 Lid margin inflammation score,Compare conjunctival and cornea inflammation 15/5/2017-31/1/2019 Conjunctival and corneal fluorescein score (Oxford grading),Compare conjunctival and cornea inflammation 15/5/2017-31/1/2019 Conjunctival and corneal Rose Bengal score (Oxford grading),Compare corneal sensitivity 15/5/2017-31/1/2019 Cochet bonnet esthesiometry,Compare quantity of tear 15/5/2017-31/1/2019 Schirmer 1 test,Compare bulbar conjunctiva redness 15/5/2017-31/1/2019 Inspection using conjunctival inflammation(bulbar redness) grading | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactPanitee Luemsamran
Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University
Outcome results
None listed