blood loss after total knee arthroplasty blood transfusion rate blood loss
Conditions
Interventions
regimen 1. 10-
15mg/kg/dose up to 1g maximum tranexamic acid will be given intravenously 15-
20 minutes before incision,
1g tranexamic acid mixed with 20ml NSS will be introduced intra-
articularly after joint capsule closure,
20ml NSS will be given intravenously 3 hours after operation.,regimen 2. 10-
15mg/kg/dose up to 1g maximum tranexamic acid mixed with NSS total of 20 ml will be given intravenously 3 hours after operation
Active Comparator Drug,Active Comparator Drug
Tranexamic Acid,Tranexamic Acid
Sponsors
None
Eligibility
Sex/Gender
All
Age
55 Years to 85 Years
Inclusion criteria
Inclusion criteria: - Primary osteoarthritis - 55-85 years of age - Platelet count of more than 100,000 - PT,PTT,INR (<1.5) within normal limits - Cr < 1.5
Exclusion criteria
Exclusion criteria: - Patients with known genetic or acquired coagulation disorder - Patients with renal failure, liver failure, heart failure, lung failure - Allergy to TXA - Patients with ischemic heart disease or arrhythmia - Previous history of DVT, PE, Stroke - Patient with secondary arthritis - Active infection, Cancer, stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood loss post operative mg/dl, ml, %/ blood sample from patient | — |
Secondary
| Measure | Time frame |
|---|---|
| blood transifusion rate post operative ml, Unit/ sample from patient | — |
Countries
Thailand
Contacts
Public Contactketirath rochanaroon
Lerdsin Hospital
Outcome results
None listed