The effect of nicardipine on the onset time and intubating conditions of cisatracurium

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20170328002

Enrollment

Registered

2017-03-28

Start date

2017-03-27

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intubation Onset time of Cisatracurium Nicardipine Intubating condition Grade of intubation Hemodynamic response after intubation

Interventions

Normal Saline 10 ml before induction agent,Nicardipine 10 mcg/kg + Normal Saline up to 10 ml,Nicardipine 20 mcg/kg + Normal Saline up to 10 ml

Placebo Comparator Drug,Experimental Drug,Experimental Drug

Normal Saline,Nicardipine 10 mcg/kg,Nicardipine 20 mcg/kg

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: - The patients receiving an elective surgery, which general anesthesia with endotracheal intubation is needed - American Society of Anesthesiologists (ASA) Physical Status 1-2 - Normal Blood Pressure

Exclusion criteria

Exclusion criteria: - The patients with Cardiac underlying diseases - The patients with a history of Niicardipine or Cisatracurium allergy - The pateints with a history of Malignant Hyperthemia - The patients with a history of Neuromuscular disease - The patients currently on cardiac pacemaker - The pregnant patients - The patients who are morbidly obese, defining as BMI of at least 35 kg per square meter - The patients who are unable to communicate to give necessary information

Design outcomes

Primary

Measure	Time frame
Effect of Nicardipine on Onset time of Cisatracurium After the Cisatracurium injection time, until maximal depression (TOF = 0) Duration since the Cisatracurium injection time to maximal depression (TOF = 0)	—

Secondary

Measure	Time frame
Grade of intubation After Intubation Intubation grade assessed by the intubating personnel,Intubating condition After intubation Intubating condition assessed by the intubating personnel,Hemodynamic response to intubation Every 1 minute until 5 minutes after intubation Blood Pressure, Heart Rate every 1 minute until 5 minutes after intubation	—

Countries

Thailand

Contacts

Public ContactSahawat Thertchanakun

Department of Anesthesiology, Faculty of Medicine, Prince of Songkhla University

sahawatt@gmail.com0869626827

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026