A randomized controlled trial of airway pressure release ventilation and low tidal volume ventilation in pediatric acute respiratory distress syndrome

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20170320002

Enrollment

Registered

2017-03-20

Start date

2017-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pediatric acute respiratory distress syndrome airway pressure release ventilation pediatric acute respiratory distress syndrome airway pressure release ventilation low tidal volume ventilation APRV ARDS

Interventions

mode of ventilator The APRV respiratory cycle is divided into 2 time periods: a longer Thigh period at the higher airway pressure (Phigh) and a much shorter Tlow period during which pressure is releas

controlled and volume&#45

controlled&#44

we use conventional mode in pressure&#45

controlled mode for pediatric acute respiratory distress syndrome with low tidal volume ventilation

Experimental Other,Active Comparator Other

Airway pressure release ventilation,conventional with low tidal volume ventilation

Eligibility

Sex/Gender

All

Age

1 Months to 15 Years

Inclusion criteria

Inclusion criteria: 1. patients who diagnosed with moderate to severe acute respiratory distress syndrome by definition of The Pediatric Acute Lung Injury Consensus Conference Group (PALICC) 2. patients aged between 1 month - 15 years old 3. all patients were obtained informed consent from parents/ legal representative

Exclusion criteria

Exclusion criteria: 1. congestive heart failure 2. air leak syndrome or preexisting cystic lung disease 3. terminal illness (life expectancy less than 3 months) 4. unstable hemodynamics

Design outcomes

Primary

Measure	Time frame
oxygenation 72 hours PaO2/FiO2	—

Secondary

Measure	Time frame
all causes of mortality 28 days mortality rate,sedation 7 days total sedation requirement ,28 days - ventilator free day 28 days duration of ventilator free day within 28 days after onset,oxygen index 72 hours mean airway pressure x FiO2/PaO2	—

Countries

Thailand

Contacts

Public ContactNavaporn Puangpakisiri

King Chulalongkorn Memorial Hospital

navaporn.puang@gmail.com+66-897998787

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026