Open label prospective randomised control study of high cut point level of procalcitonin-guided antibiotic therapeutic protocol in surgical critically ill patient

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20170210001

Enrollment

100

Registered

2017-02-10

Start date

2016-10-18

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

This study aim to compare the antibiotic free day and time of antibiotic use between procalcitonin group and usual care group For the Protocol in Procalcitonin group as below and we use procalcitoi procalcitonin

Interventions

We collect the blood for serum procalcitonin at day1 in patient suspected bacterial infection and follow the level in day3 /8 or day that the physician decided the clinical was cured,We collect time o

3&#44

8 of treatment but the physician was blinded the result

Experimental Procedure/Surgery,No Intervention Other

Procalcionin group,usual care

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1.Suspect bacterial infection (HAP,VAP,soft tissue and skin infection,intraabdominal infection, blood stream infection, UTI) 2.Age >18 yr 3.Admit in surgical ICU , surgical sub ICU and sub ICU trauma 4. Patient or their legal representative informed and consented 5. No antibiotic for treatment in 7 days prior to enroll, except for prophylaxis 6.Fever or subtemperature of unknown source during post op 7.Fever post op during antibiotic for treatment

Exclusion criteria

Exclusion criteria: Exclusion criteria 1.Pregnancy 2.HIV or ANC<500 3.Immunocompromised patient or patient who received chemotherapy within 45 days 4.Moribund patient 5. Suspected CNS infection, Endocarditis, Osteomyelitis, Aortitis

Design outcomes

Primary

Measure	Time frame
antibiotic time and antibiotic free day 3 day days of antibiotic use	—

Secondary

Measure	Time frame
mortality rate, rate of reinfection still recording number of reinfection patient	—

Countries

Thailand

Contacts

Public ContactMudjalin Areerug

Faculty of medicine, Chiangmai university

mudjalin.areerug@gmail.com0882525532

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026

Open label prospective randomised control study of high cut point level of procalcitonin&#45;guided antibiotic therapeutic protocol in surgical critically ill patient