Kidney transplantation AUC,
Conditions
Interventions
Sponsors
Faculty of Pharmaceutical Science, Chulalongkorn University, Thailand
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.First kidney transplantation 2.Being prescribed MMF 1.5 g/day with tacrolimus and prednisolone as maintenance immunosuppressive agent to prevent allograft rejection
Exclusion criteria
Exclusion criteria: 1.More than one organ transplantation 2.Positive cross match 3.ABO-incompatible blood group 4.Panel reactive antibody (PRA) more than 50% 5.Patient who require treatment other than that those in KCMH protocol for kidney transplantation which may interfere MPA pharmacokinetics 6.Systemic infection 7.Hypersensitivity to MMF, tacrolimus, or prednisolone 8.History of bowel or intestine surgery 9.Liver dysfunction (AST > 65 U/L, ALT > 65 U/L, total bilirubin > 1.4 mg/dL, direct bilirubin > 0.3 mg/dL) 10.Being prescribed any concomitant drug as follow: sevelamer carbonate, rifampicin, magnesium or aluminum-containing antacids, cholestyramine, norfloxacin and metronidazole
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MPA exposure Day 3 post-transplantation Immunoassay | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute rejection within 30 days post-transplantation biopsy | — |
Countries
Thailand
Contacts
Public ContactSomratai Vadcharavivad
Chulalongkorn University
Outcome results
None listed