The musculoskeletal system is composed of muscles and bones. Aging process has been hypothesized to play a role in the loss of muscle and bone. Low muscle mass,
Conditions
Interventions
Participatns are taking vitamin D2 (Ergocalciferal) in opaque capsule 2 tablets per week duration 12 wk,Participatns are taking placebo in opaque capsule 2 tablets per week.duration 12 wk
Active Comparator Drug,Placebo Comparator Drug
vitaminD 40000 IU,placebo
Sponsors
Ratchadapiseksompotch Fund
Eligibility
Sex/Gender
Female
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Thai postmenopausal women age 45 - 60 years 2. Natural menopause at least 1 year 3. Serum 25-hydroxy vitamin D < 20 ng/ml 4. Women who are willing to participate in the study
Exclusion criteria
Exclusion criteria: 1. Women who used vitamin D contained medicine within 12 weeks 2.Women with history of neurological diseases 3.Women with history of liver disease or having abnormal liver function test 4.Women with history of renal disease or having abnormal renal function test 5.Women with history of hyperparathyroidism disorder 6.Women with history of uncorrected visual impairment 7.Women with history of musculoskeletal disease 8.Women who used of some medication such bisphosphonate, estrogen, fluoride, tamoxifen and calcitonin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| muscle strength 12 week hang grip strength test | — |
Secondary
| Measure | Time frame |
|---|---|
| muscle mass 12 week BIA ,muscle cross sectional area 12 week ultrasound | — |
Countries
Thailand
Contacts
Public ContactChanakarn Suebthawinkul
Reproductive medicine unit Department of Obstetrics Gynaecology, Faculty of Medicine Chulalongkorn U
Outcome results
None listed