Obese children with NAFLD
Conditions
Interventions
Placebo contains Maldextrin 2.3g/sachet which look similar to pre-
pro biotic mixture,BIOLIFE A.B. PRE & PRO,
a powder mix in sachet which contains prebiotic & probiotics. The prebiotic used in this product is chicory inulin (2.24 gram/sachet). Inulin is a soluble dietary fiber and a natural prebiotic. The p
placebo (maltodextrin),powder mix containing chicory inulin,
Lactobacillus acidophilus LA5,
and Bifidobacterium lactis BB12
Sponsors
The Ratchadaphiseksomphot Fund, Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: Obese children with NAFLD, age 6 to 18 years - Obese is defined by weight more than 2SD in the same gender and same age. - NAFLD is defined by the presence of steatosis with controlled attenuation parameter (CAP) values ≥250 dB/m from Fibroscan with CAP.
Exclusion criteria
Exclusion criteria: 1.Fatty liver from metabolic liver disease, viral hepatitis, Wilson disease, autoimmune hepatitis 2.History of hepatotoxic drug or substance used 3.Allergic or serious ADR to probiotics and prebiotics 4.Poor compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hepatic fat content 16 weeks controlled attenuation parameter (CAP) by fibroscan | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver fibrosis 16 weeks Liver stiffness measurement (LSM) by fibroscan,Body mass index Z-score 16 weeks 2007 WHO child growth references | — |
Countries
Thailand
Contacts
Public ContactHansamon Poparn
Chulalongkorn University
Outcome results
None listed