Hypothyroidism Hypothyroidism Carbimazole
Conditions
Interventions
None listed
Sponsors
New Damietta Faculty of Medicine, Al-Azhar University, Egypt
None,None
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients diagnosed of primary hypothyroidism and were on stable doses of LT4 for at least 6 months, but were not tolerating it without reaching a thyrotoxic state.
Exclusion criteria
Exclusion criteria: patients with: congenital hypothyroidism, any thyroidectomy (except subtotal for GD), thyroid diseases treated with radioiodine, coronary heart disease, anemia, uncontrolled hypertension or diabetes mellitus, significant liver, renal or respiratory disease. Subjects using antidepressants or other drugs that may influence thyroid function or alter T4 metabolism. Pregnant or lactating women or those planning for pregnancy during the study period were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levothyroxine tolerance 10 weeks Study-specific questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression 10 weeks Montgomery-Asberg Depression Rating Scale (MADRS),Thyroid function tests 10 weeks solid-phase, competitive chemiluminescent enzyme immunoassay on IMMULITE system | — |
Countries
Egypt
Contacts
Public ContactMohamed Aboalabbas
New Damietta Faculty of Medicine, A-lAzhar University
Outcome results
None listed