Skip to content

A Novel Therapy for cocaine dependence during abstinence: A randomized clinical trial

A Novel Therapy for cocaine dependence during abstinence: A randomized clinical trial

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20170112001
Enrollment
100
Registered
2017-01-21
Start date
2015-12-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The inclusion criteria for participation in this study were: 1) having the respective age between 18 and 31&#44

Interventions

The values of boosters in this study were three thousands&#44
fifteen thousands and thirty thousands (about 1&#44
5 and 10 dollar respectively). Payments in this program were at most 550 dollars (to each group) and were similar to other remedial programs (51&#44
52). The whole cost of boosters during the period of three month was 1200 dollars. The urine test band was used to investigate cocaine metabolite in four weeks in form of two weekly evaluations and th
Creatinine and PH and the threshold of 300 Nano grams in milliliter was considered for urine analysis. For negative urine samples (urine shortage of cocaine) coupon was specified. rewards for negative
for second sample was 3 dollar&#44
and for third negative test was considered 5 dollars and in the next stages 1.25 dollar was added to the reward value which after the urine negative test report was given to the participants. Coupons
participants were motivated to continue to take part in the study by email. All of the participants signed a contract in terms of expectations of remedial program (27). Also urine samples were taken f
all the participants of the study for the second time but this time in form of a posttest were evaluated through
Experimental Behavioral

Sponsors

non
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 31 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria for participation in this study were: 1) having the respective age between 18 and 31, 2) History of one months of cocaine avoidance, and 3) having at least the educational level of Diploma.

Exclusion criteria

Exclusion criteria: Also the exclusion criteria were: 1) Report of positive urine test during remedial period, 2) Taking supplementary drug and psychological remedies, and 3) three continuous weeks of absence from participation in remedial meetings.

Design outcomes

Primary

MeasureTime frame
The results showed that all three types of treatment played a efficacy in reducing the craving 12-week ANCOVA Univariate Model ,scores of craving was 12.04 with TPM, 13.89 with CM, 10.92 with Mix (p = 0.01) and 16.89 in control 12-week ANCOVA Univariate Model

Secondary

MeasureTime frame
The highest variance explaining the changes in craving was assigned to the combined mix treatment. 12-week Scheffe’s post hoc

Contacts

Public Contactbijan pirnia

phD student

b.pirnia@usc.ac.ir+9802122081450

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026