Occurrence of any abnormal clinical symptoms and signs Rash Angioedema Rhinitis Wheezing GI involvement Anaphylaxis Non-
Conditions
Interventions
Perform oral provocation test without skin testing.
Experimental Procedure/Surgery
PSU 2 steps challenge
Sponsors
Prince of Songkla University Ethics Committee of Human Research
Eligibility
Sex/Gender
All
Age
No minimum to 15 Years
Inclusion criteria
Inclusion criteria: History of urticaria/angioedema or maculopapular exanthema eruption more than 2 hour after amoxicillin or amoxicillin/clavulanic acid administration
Exclusion criteria
Exclusion criteria: - History of anaphylaxis - History of life-threatening non-IgE-mediated eg. Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophillia and systemic syndrome (DRESS), acute generalized exanthematous pustulosis (AGEP), exfoliative dermatitis, vasculitis à¹à¸¥à¸° severe maculopapular eruption (MPE) - Uncontrolled chronic disease - Patient who are at risk of severe anaphylaxis eg, systemic mastocytosis, hereditary angioedema, beta-blockers or angiotensin-converting enzyme (ACE) inhibitors using
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety of amoxicillin provocation test using PSU 2 steps challenge within 7 days since the start of drug provocation test Occurence of any adverse reaction from oral amoxicillin provocation test | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactDuangdee Wantanaset
Unaffiliated
Outcome results
None listed