No adverse events. Brain stimulation,
Conditions
Interventions
The real LF-
rTMS session lasted for 20 minutes. Subsequently the participants underwent task-
specific training of the paretic hand for 1 hour while the non-
paretic hand was constrained by a mitt.,The sham LF-
paretic hand was constrained by a mitt.
Real low-
frequency repetitive transcranial magnetic stimulation with motor training,Sham low-
frequency repetitive transcranial magnetic stimulation with motor training
Sponsors
Faculty of Physical Therapy, Mahidol University
Faculty of Graduate Studies,
Mahidolniversity
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were as follows: (1) onset of subcortical ischemic or hemorrhage stroke within 1-6 months as verified by medical records or CT/MRI findings, (2) age of 20-79 years, (3) right handedness as evaluated using the Edinburgh Handedness Inventory, (4) mild to moderate impairment of an upper extremity based on the Fugl-Meyer Assessment (FMA), (5) able to understand and follow simple commands as evaluated by the 2002 Thai version of the Mini Mental State Examination (MMSE), (6) able to perform mass extension of finger (score on the hand section of the FMA of at least 1), (7) able to sit independently for more than one hour, (8) normal or corrected hearing and vision, and (9) no motor aphasia, sensory aphasia, or global aphasia.
Exclusion criteria
Exclusion criteria: (1) contraindication of rTMS, such as seizures or an intracranial metallic implant, as confirmed by a TMS screening questionnaire, (2) other neurological and musculoskeletal problems affecting the arm, hand, or trunk that might interfere with task achievement, such as pain in at least 3 of 5 joints (of the upper extremities) based on the joint pain domain of the FMA (FMA pain score of zero), (3) lesions in other brain areas such as the brainstem or cerebellum or brain damage that was bilateral or of non-vascular etiology such as traumatic brain injury, and (4) receipt of task-specific training during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| corticospinal excitability of the non-lesioned hemisphere baseline, after the LF-TMS session, and immediately, 1 week, and 2 weeks after motor training Transcranial Magnetic Stimulation | — |
Secondary
| Measure | Time frame |
|---|---|
| by total movement time on the Wolf Motor Function Test of 2 hands baseline, after the LF-TMS session, and immediately, 1 week, and 2 weeks after motor training Clinical measurement | — |
Countries
Thailand
Contacts
Public ContactJarugool Tretriluxana
Faculty of Physical Therapy
Outcome results
None listed