Efficacy of thiamine in treatment of post-cardiac arrest patients: a randomized controlled pilot study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20161226001

Enrollment

Unknown

Registered

2016-12-26

Start date

2016-12-24

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

&#45

Interventions

Thiamine is a vitamin B1. We give 100 mg of thiamine intravenously every 8 hours for 7 days to patients. ,Normal saline is an intravenous fluid.

Active Comparator Drug,Placebo Comparator Drug

Thiamine ,Normal saline

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Adults > 18 years old - Post cardiac arrest patients with successful return of spontaneous circulation - unconsciousness (Glasgow Coma Scores < 8)

Exclusion criteria

Exclusion criteria: - No informed consent from next of kins - Palliative care patients - Unconscious patients or vegetative patients before cardiac arrest - Need thiamine treatments by physician

Design outcomes

Primary

Measure	Time frame
mortality 28 day death	—

Secondary

Measure	Time frame
Neurological outcome at hospital discharge cerebral performance catagories ,Brain marker at 72 hours S100B,Lactate at 24, 48 and 72 hours lactate levels	—

Countries

Thailand

Contacts

Public ContactVeerapong Vattanavanit

Faculty of medicine, Prince of Songkla University

vveerapong@gmail.com+66848456228

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Efficacy of thiamine in treatment of post&#45;cardiac arrest patients: a randomized controlled pilot study