sepsis septic shock
Conditions
Interventions
Normal saline solution 2 ml IV injection,Calcitriol 2 micrograms (2 ml) IV injection
Placebo Comparator Drug,Active Comparator Drug
Normal saline solution,1,
25-
dihydroxyvitamin D3 (calcitriol)
Sponsors
Faculty of Medicine Siriraj Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Patient age >/= 18 years old and Severe sepsis/ septic shock (Hospital acquired infection) and Admitted in hospital more than 48 hours
Exclusion criteria
Exclusion criteria: Hypercalcemia (serum calcium >/= 10 mg/dl) Hyperphosphatemia (serum phosphate >/= 6 mg/dl) Current therapy with nutritional vitamin D at any doses History of primary parathyroid disease Metabolic bone disease Expected to die within 48 hours Pregnancy History of transplantation Malignancy with poor prognosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mortality rate 28 days mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| Organ failure after drug administration new ventilator requirement, new RRT in 24, 48 hours and duration of vasopressor requirement,Severity of illness after drug administration SOFA score improvement, length of hospital stay and hospital mortality ,Vitamin D status inclusion date serum vitamin D level | — |
Countries
Thailand
Contacts
Public ContactWarinthip Mahapasuthanon
Faculty of Medicine Siriraj Hospital
Outcome results
None listed