A study of retinal microvascular changes in Diabetic Macular Edema using the swept - source optical coherence tomography angiography (OCTA) after being treated with Anti-Vascular endothelial growth factors (Anti-VEGF)

A study of retinal microvascular changes in Diabetic Macular Edema using the swept â€“ source optical coherence tomography angiography (OCTA) after being treated with Anti-Vascular endothelial growth factors (Anti-VEGF)

Status

Recruiting

Phases

Phase 3

Study type

Observational

Source

TCTR

Registry ID

TCTR20161010005

Enrollment

Registered

2016-10-10

Start date

2016-10-17

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

DME Microaneurysm changes Enlarged FAZ Zone Capillary non perfusion zone Central&#45

Interventions

DME treated with Bevacizumab,DME treated with Aflibercept ,DME treated with Ranibizumab

Treatment,Treatment,Treatment

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Patients diagnosed with Diabetic Macular Edema (DME). - Age > 18 years of age who have signed an inform consent. - Candidates to be treated with Intravitreous Anti-VEGF ( Aflibercept , Bevacizumab and Ranibizumab ) - No history of Anti-VEGF treatment within 3 months. - No history of retina surgery.

Exclusion criteria

Exclusion criteria: - Presence of severe media opacities. - Patients who have other disease: monoculus, eye injuries , glaucoma, uveitis, retinal vein occlusion, retinal arterial occlusion, hereditary and degenerative macular disease, retinal and choroidal detachment. - Any previous treatment for DME e.g. Focal / Grid LASER , IVT steroid injection/implant with in 6 months.

Design outcomes

Primary

Measure	Time frame
MIcroaneurysm in ETDRS Grid 1 year Image J Software	—

Secondary

Measure	Time frame
FAZ 1 year Image J ,Capillary non perfusion area 1 year Image J	—

Contacts

Public ContactPear Ponsacharoennont

Faculty of Medicine, Chulalongkorn University

pearee@gmail.com022564420

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

A study of retinal microvascular changes in Diabetic Macular Edema using the swept &#45; source optical coherence tomography angiography (OCTA) after being treated with Anti&#45;Vascular endothelial growth factors (Anti&#45;VEGF)