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Comparison of retinal nerve fiber layer defect detection between color, red-free, and High-Dynamic-Range (HDR) disc photography

Comparison of retinal nerve fiber layer defect detection between color, red-free, and High-Dynamic-Range (HDR) disc photography

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20161008002
Enrollment
36
Registered
2016-10-08
Start date
2016-09-30
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma High&#45

Interventions

Disc photo from glaucoma patients,Disc photo from glaucoma with lens opacity patients,Disc photo from normal volunteers,Disc photo from normal volunteers with lens opacity patients
Diagnostic,Diagnostic,Diagnostic,Diagnostic
Glaucoma group,Glaucoma + media opacity group,Control group,Control + media opacity group

Sponsors

Ratchadaphiseksomphot Fund
Lead Sponsor
Ratchadaphiseksomphot Fund
Collaborator

Eligibility

Sex/Gender
All
Age
41 Years to 80 Years

Inclusion criteria

Inclusion criteria: Glaucoma group 1. Age > 40 years 2. Diagnosis by glaucoma specialist 3. At least 2/3 of the following 3.1 Vertical cup to disc ratio greater than 97.5th percentile of normal population 3.2 RNFLD in C-DP or OCT 3.3 Visual field defect in SAP correlated to C-DP or OCT Glaucoma + media opacity group 1. Age > 40 years 2. Diagnosis by glaucoma specialist 3. At least 2/3 of the following 3.1 Vertical cup to disc ratio greater than 97.5th percentile of normal population 3.2 RNFLD in C-DP or OCT 3.3 Visual field defect in SAP correlated to C-DP or OCT 4.Lens opacity according to LOCS III criteria : at least 1/3 of 4.1 lens opacity 2.0 for nuclear (NO) cataract 4.2 lens opacity 4.0 for cortical cataract (C) 4.3 any posterior subcapsular opacity (P) 5. Image quality (compare with standard disc photo) : at least 1/3 of 5.1 Poor overall image clarity 5.2 Poor defined blood vessel edges 5.3 Poor quality of RNFL Control group 1. Age > 40 years 2. Vertical cup to disc ratio less than 97.5th percentile of normal population 3. No pathological change in RNFL by C-DP, OCT and SAP Control + media opacity group 1. Age > 40 years 2. Vertical cup to disc ratio less than 97.5th percentile of normal population 3. No pathological change in RNFL by C-DP, OCT and SAP 4.Lens opacity according to LOCS III criteria : at least 1/3 of 4.1 lens opacity 2.0 for nuclear (NO) cataract 4.2 lens opacity 4.0 for cortical cataract (C) 4.3 any posterior subcapsular opacity (P) 5. Image quality (compare with standard disc photo) : at least 1/3 of 5.1 Poor overall image clarity 5.2 Poor defined blood vessel edges 5.3 Poor quality of RNFL

Exclusion criteria

Exclusion criteria: 1. Retinal or neurological eye disease 2. Intraocular trauma 3. Uncooperative patient 4. Contraindicate for pupil dilatation 5. Poor quality OCT 6. Unreliable VF perimetry 7. Spherical refractive error more than five diopters

Design outcomes

Primary

MeasureTime frame
Capability of retinal nerve fiber layer defect detection between color, red-free, and HDR disc photo Cross-sectional sensitivity, specificity, PPV, NPV, Mean difference ± SD of sensitivity and specificity—

Secondary

MeasureTime frame
Capability of RNFLD detection in images with media opacities between 3 methods Cross-sectional sensitivity, specificity, PPV, NPV, Mean difference ± SD of sensitivity and specificity—

Countries

Thailand

Contacts

Public ContactUbonwan Rasaruck

Department of Opthalmology, Chulalongkorn University

dr.ubonwanr@gmail.com0832645775

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026