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The Retinal Pigment Epithelial Detachment changes in Aged-related macular degeneration treated with Aflibercept, Ranibizumab and Bevacizumab

The Retinal Pigment Epithelial Detachment changes in Aged-related macular degeneration treated with Aflibercept, Ranibizumab and Bevacizumab

Status
Recruiting
Phases
Phase 4
Study type
Observational
Source
TCTR
Registry ID
TCTR20161007004
Enrollment
60
Registered
2016-10-07
Start date
2016-10-10
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

wet AMD RPED RPED Retinal Pigment Epithelial Detachment AMD Age&#45

Interventions

VEGF administered to the patients is routine treatment care as well as OCT scanning from SPECTRALIS SD&#45
OCT after treatment in each visit., The patients with RPED secondary to wet AMD who have been treated with anti&#45
OCT after treatment in each visit.
Treatment,Treatment,Treatment
The patients with RPED secondary to wet AMD who have been treated with anti&#45
VEGF at King Chulalongkorn Memorial Hospital from Jan 2010 to Jan 2017 who is eligible to inclusion criteria will be enrolled to the study. Intravitreal anti&#45
The patients with RPED secondary to wet AMD treated with intravitreal Bevacizumab,The patients with RPED secondary to wet AMD treated with intravitreal Ranibizumab,The patients with RPED secondary

Sponsors

Faculty of Medicine, Chulalongkorn University
Lead Sponsor
N/A,N/A
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Newly diagnosed wet AMD patient confirmed by FFA or OCT and diagnosed by retina specialist in 2010 to 2017 2. Presence of PED at the time of diagnosis 3. No history of previous macular laser treatment or photodynamic therapy 4. No concurrent other macular diseases in the study eye Obtained OCT scanning from SPECTRALIS SD-OCT

Exclusion criteria

Exclusion criteria: 1. Poor quality of OCT image at baseline and at 12th month visit 2. Lost follow up before 6th month visit 3. Presence of RPE rip after initial Anti VEGF treatment

Design outcomes

Primary

MeasureTime frame
Height and area of Pigment epithelial detachment 6 months Optical coherence tomography

Secondary

MeasureTime frame
Visual acuity 6 months ETDRS chart,Sub retinal fluid 6 months Optical coherence tomography,Central foveal thickness 6months Optical coherence tomography,Number of injections and visits 6months From chart review

Contacts

Public ContactPear Pongsachareonnont

Faculty of Medicine, Chulalongkorn University

pearee@gmail.com02-256-4142

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026