The physiologic study of high-flow nasal oxygen cannula in patients with chronic obstructive pulmonary disease with acute exacerbation requiring ventilator support

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20160902001

Enrollment

Registered

2016-09-02

Start date

2016-09-01

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with chronic ostructive pulmonary disease presented with acute exacerbation and requiring non&#45

Interventions

Subjects will receive HFNC starting from flow rate at 10 LPM and gradually increase to 20&#44

30&#44

40&#44

50 and 60 LPM. Each step will take 15 minutes.

Experimental Device

High&#45

flow nasal oxygen cannula

Eligibility

Sex/Gender

All

Age

40 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Age 40-85 years old 2. Patients who was diagnosed COPD classified by GOLD criteria (post-bronchodilator FEV1/FVC /=45 mmHg) - Respiratory rate > 24 breaths/min - Accessory muscles use or abdominal paradox breathing

Exclusion criteria

Exclusion criteria: 1. pH < 7.25 2. Severe hypoxemia 3. Alteration of consciousness and uncooperative (GCS < 8) 4. Hemodynamic instability or serious cardiac problem e.g hypotension, malignant arrhythmia, myocardial ischemia 5. Facial abnormality or recent facial/upper GI tract surgery 6. Uncontrolled airway or upper GI bleeding 7. Contraindication for insertion of esophageal balloon catheter - ulcer, varices, tumor, recent esophageal/gastric surgery, bleeding diathesis or allergy to lidocaine

Design outcomes

Primary

Measure	Time frame
Patient's work of breathing every 15 minutes Esophageal pressure-time product	—

Secondary

Measure	Time frame
Respiratory variables every 15 minutes Respiratory rate, oxygen saturation, transcutaneous CO2 monitoring,Hemodynamic variables every 15 minutes Blood pressure, heart rate,Dyspnea every 15 minutes Dyspnea visual analog scale	—

Countries

Thailand

Contacts

Public ContactNuttpol Rittayamai

Faculty of Medicine Siriraj Hospital

nuttapol.rit@mahidol.ac.thy+6624197757

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026

The physiologic study of high&#45;flow nasal oxygen cannula in patients with chronic obstructive pulmonary disease with acute exacerbation requiring ventilator support