All patients had severe knee osteoarthritis requiring total knee arthroplasty in 2 months All patients must be fit for surgery and passed preoperative medical check up knee osteoarthritis oxidative stress antioxidant anti-
Conditions
Interventions
Placebo (identical appearance) 1 capsule/day for 2 months,Vitamin E 400 iu,
1 capsule/day for 2 months
Placebo Comparator Drug,Active Comparator Drug
Placebo,Vitamin E
Sponsors
Ratchadaphiseksomphot Endowment Fund
Department of Orthopaedic,
Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: ≥18 years of age Clinically diagnosed with knee OA according to the criteria of the American College of Rheumatology Radiographically diagnosed with severe knee OA (grade 3–4) as defined by the Kellgren–Lawrence classification [17] Scheduled for total knee arthroplasty (TKA) within 2 months
Exclusion criteria
Exclusion criteria: Established diagnosis of a bleeding disorder Currently used vitamin E-containing drugs or dietary supplements On anticoagulants, or antiplatelet therapy Had a vitamin E allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of oxidative stress and antioxidant Blood were test before atart intervention and 2 month after intervention; The synovial fluid was obt Level of oxidative stress and antioxidant were measured in blood and synovial fluid (knee) | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee society score, WOMAC score, adverse affect of vitamin E Before intervention and 2 month after intervention Interview patient by researcher | — |
Countries
Thailand
Contacts
Public ContactAree Tanavalee
Chulalongkorn University
Outcome results
None listed