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Effect Of Sodium Thiosulfate On Arterial Stiffness in End-Stage Renal Disease Patients Undergoing Chronic Hemodialysis

Effect Of Sodium Thiosulfate On Arterial Stiffness in End-Stage Renal Disease Patients Undergoing Chronic Hemodialysis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20160814001
Enrollment
50
Registered
2016-08-14
Start date
2016-07-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ESRD patients undergoing chronic HD Presence of arterial stiffness measured by cfPWV and CAVI method Vascular calcification Inflammation in ESRD patients undergoing chronic HD ESRD chronic hemodialysis arterial stiffness vascular calcification sodium thiosulfate cPWV CAVI CT coronary calcium score

Interventions

25% Sodium thiosulfate 12.5 gram intravenous injection during last hour of hemodialysis 2 times per week&#44
total duration 24 weeks,No intervention is given in this group of subject
Active Comparator Drug,No Intervention No treatment
25% Sodium Thiosulfate,Control

Sponsors

Jongkolnee Nidhi foundation Fund
Lead Sponsor
Ratchadapiseksompotch Fund,The kidney foundation of Thailand
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age older than 18 years old 2.Dialysis vintage at least 6 months’ duration 3.Hemodialysis frequency 2 or 3 times per week 4.Presence of increased arterial stiffness measured by cfPWV (cfPWV>=10 m/s) 5.Informed consent 6.Can follow the research methodology and follow up regularly

Exclusion criteria

Exclusion criteria: 1.Life expectancy less than 6 months 2.Missing a dialysis session more than twice per month 3.Active malignancy or infection 4.Known pregnancy 5.Recently use of oral or IV corticosteroid therapy within 1 month (dose more than 5 mg of prednisolone or equivalent) 6.Allergy or known sensitivity to sodium thiosulfate 7.Intact PTH more than 9 times of UNL in previous 3 months ( using 2nd generation intact PTH more than 585 pg/ml) 8.Abnormal limb that cannot be measured by cfPWV eg. above or below knee amputation, severe PAD etc.

Design outcomes

Primary

MeasureTime frame
Arterial stiffness 24 weeks carotid-femoral pulse wave velocity (cfPWV)—

Secondary

MeasureTime frame
Vascular calcification 24 weeks CT Coronary Artery Calcium score,Inflammatory marker 24 weeks high-sensitivity CRP (hsCRP),Arterial stiffness (BP independent method) 24 weeks Cardio-Ankle Vascular Index (CAVI),Arterial siffness 48 weeks Carotid-femoral pulse wave velocity (cfPWV)—

Countries

Thailand

Contacts

Public ContactDonlawat Saengpanit

King Chulalongkorn Memorial Hospital

donlawats@hotmail.com+66897899852

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026