sepsis septic shock sepsis inferior vena cava diameter variation static central venous pressure ultrasound fluid resuscitation mortality
Conditions
Interventions
Central venous pressure (CVP) of less than 8 mmHg, and 8 mmHg or more were considered as fluid responsiveness, and fluid non-responsiveness, respectively.,In dynamic inferior vena cava (IVC) group, th
Active Comparator Procedure/Surgery,Experimental Procedure/Surgery
static central venous pressure-guided fluid resuscitation,dynamic inferior vena cava-guided fluid resuscitation
Sponsors
Thammasat University
Eligibility
Sex/Gender
All
Age
15 Years to 100 Years
Inclusion criteria
Inclusion criteria: All of the following characteristics: 1. age of 15 years old or more 2. Quick SOFA of 2 or more 3. SOFA of 2 or more 4. unstable hemodynamics (SBP <90 mmHg or decrease in SBP >40 mmHg from baseline or MAP <70 mmHg for 6 hours or less 5. fluid resuscitation required for unstable hemodynamics
Exclusion criteria
Exclusion criteria: One of the following characteristics: 1. pregnant woman 2. cardiogenic pulmonary edema 3. inability to lie down (e.g., scoliosis) 4. limited measurement of IVC diameter by ultrasound (e.g., abdominal mass compressing IVC) 5. difficulty in performing central venous catheterization or CVP measurement (e.g., superior vena cava obstruction)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day mortality 30 days survival status | — |
Secondary
| Measure | Time frame |
|---|---|
| macrovascular targets 6 hours mean arterial pressure MAP of 65 mmHg or more, urine output of 0.5 milliliter(s) per kilogram per hour or more,microvascular targets ScvO2 of 70% or more, lactate clearance of 10% or more 6 hours 6 hours ScvO2 of 70% or more, lactate clearance of 10% or more,duration of shock time at MAP of 65 mmHg or more and adequate tissue perfusion time from treatment initiation to MAP of 65 mmHg or more and adequate tissue perfusion,total volume of fluid administration 72 hours total volume of fluid administration and total volume of fluid administration per kilogram of body weight,accumulated dose of norepinephrine time at norepinephrine cessation accumulated dose of norepinephrine and accumulated dose of norepinephrine per kilogram of body weight,endotracheal intubation with mechanical ventilation time at endotracheal intubation and initiation of mechanical ventilation endotracheal intubation and initiation of mechanical ventilation,duration of mechanical ventilation time at cessation of mechanical ventilation time from initiation to cessation of mechanical ventilation,hospital length of stay time at discharge from hospital time from hospital admission to hospital discharge,intensive care unit length of stay time at discharge from intensive care unit time from intensive care unit admission to intensive care unit discharge | — |
Countries
Thailand
Contacts
Public ContactThiti Sricharoenchai
Faculty of Medicine, Thammasat University
Outcome results
None listed