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The effect of preopertive pregabalin administration in postoperative pain control after laminectomy and instrumented fusion in degenerative lumbar spine disease: a randomized double-blind placebo controlled study

The effect of preopertive pregabalin administration in postoperative pain control after laminectomy and instrumented fusion in degenerative lumbar spine disease: a randomized double-blind placebo controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20160729003
Enrollment
90
Registered
2016-07-29
Start date
2016-07-29
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

degenertive lumbar spine disease pregabalin morphine consumption VAS score

Interventions

pregabalin (75 mg) 2 capsules before operation,pregablin (150mg) 2 capsules before operation,2 placebo capsules before operation
Active Comparator Drug,Active Comparator Drug,Placebo Comparator No treatment
A,B,C

Sponsors

Siriraj Hospital, Mahidol University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1.patients with degenertive lumbar spine underwent decompressive laminectomy and instrumented spinal fusion in Siriraj Hospital 2.Age more than 18 3.Enable to communicate and co-operable

Exclusion criteria

Exclusion criteria: 1.Allergy to opioids, gabapentin, Pregabalin or sulfonamides 2.contraindication for usage of morphine, pethidine, fentanyl or selective COX-2 inhibitors 3.patient dilivered pregabalin or gabapentin in 48 hrs. 4.patients have severe pain after stop gabepentin before surgery 5.BMI more than 35 kg/sq.m. 6.ASA classification greater than 3 7.patient unable to use IV PCA

Design outcomes

Primary

MeasureTime frame
Morphine consumption 48 hours postoperatively doses of morphine that patients used after operation—

Secondary

MeasureTime frame
time to first IV analgesic Minute to first IV analgesic drug dilivered Minute to first IV analgesic drug dilivered,Pain score at 6, 24,48,72 hours VAS—

Countries

Thailand

Contacts

Public ContactSirichai Wilartratsami

Unaffiliated

sirichai_w@hotmail.com0813721107

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026