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Efficacy of intravenous 100 mcg carbetocin versus intravenous 5 units oxytocin for prevention of immediate postpartum hemorrhage after normal vagina delivery among high risk prenancies; a tripple-blinded randomized controlled trial

Efficacy of intravenous 100 mcg carbetocin versus intravenous 5 units oxytocin for prevention of immediate postpartum hemorrhage after normal vagina delivery among high risk prenancies; a tripple-blinded randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20160715004
Enrollment
Unknown
Registered
2016-07-15
Start date
2016-08-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pregnancy normal vaginal delivery Carbetocin Oxytocin normal vaginal delivery Postpartum hemorrhage

Interventions

Oxytocin 5 units IV slow push,Carbetocin 100 mcg IV slowly push
Active Comparator Drug,Experimental Drug
Oxytocin,Carbetocin

Sponsors

Siriraj Routine to Research Unit
Lead Sponsor
Siriraj Routine to Research Unit
Collaborator

Eligibility

Sex/Gender
Female
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Thai pregnant woman 2. age at least 20 years old 3. Pregnancy age at least 34 weeks gestation 4. normal vaginal delvery 5. high risk for PPH including previous history of PPH, induction or augmentation of labour, tocolytic drug before delivery, prolonged active phase of labour, precipitate labour, grand multipara, overdistended uterus, uterine structural abnormality

Exclusion criteria

Exclusion criteria: 1. being active labour 2. Contraindication to carbetocin 3. allergy to oxytocin or carbetocin 4. obstetrics complication including preeclampsia and abnormal placentation

Design outcomes

Primary

MeasureTime frame
incidence of postpartum hemorrhage 24 hours after normal vaginal delivery percentage of immediate postpartum hemorrhage—

Secondary

MeasureTime frame
Additional uterotonic drug used after delivery 24 hours after normal vaginal delivery percentage of patient and dosage of additional uterotonic agents,Complication after delivery 24 hours after normal vaginal delivery percentage of Blood transfusion, ICU admission, Surgical management—

Contacts

Public ContactTripop Lertbunnaphong

Faculty of Medicine. Siriraj Hospital. Mahidol University

tripop2520@hotmail.com+66818749282

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026