COPD patients with no exacerbation Non-
Conditions
Interventions
Fifty clinically stable male patients with mild to severe COPD ,Fifty non-
smoking male controls
Basic Science,Basic Science
COPD,controls
Sponsors
Faculty of Medicine, Khon Kaen University
Eligibility
Sex/Gender
Male
Age
45 Years to 83 Years
Inclusion criteria
Inclusion criteria: Group 1. The diagnosis of COPD and its severity were determined using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2015 guidelines [1]. COPD patients with GOLD stage I (FEV1 ≥ 80% predicted), II (50%  FEV1 < 80% predicted), III (30%  FEV1 < 50% predicted), and IV (FEV1 < 30% predicted) numbered 14, 19, 16, and 1 patients, respectively. None of the COPD patients had COPD exacerbation within the three months prior to the start of the study. Group 2. non-smoking healthy male controls
Exclusion criteria
Exclusion criteria: Subjects meeting any of the following criteria were excluded from the study: history of cardiac arrhythmias or potential ECG alterations, history consistent with heart disease, diabetes mellitus, hypertension or other concomitant respiratory diseases, central or peripheral nervous system diseases, and electrolyte imbalance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oxidative stress 12/01/2015 to 15/02/2016 MDA,cardiac autonomic control 12/01/2015 to 15/02/2016 HRV,lung function 12/01/2015 to 15/02/2016 FVC, FEV1, MEF, and PEF | — |
Secondary
| Measure | Time frame |
|---|---|
| lung function 12/01/2015 to 15/02/2016 FVC, FEV1, MEF, and PEF | — |
Countries
Thailand
Contacts
Public ContactWilaiwan Khrisanapant
Khon Kaen University
Outcome results
None listed