Major depressive disorder Depressive episode extended release venlafaxine sertraline Major depressive disorder Hamilton'
Conditions
Interventions
In this study,
34 patients who complained of major depressive disorder were randomly allocated into two groups (16 patients in sertraline group and 18 subjects in venlafaxine group) to receive flexible dose of sertr
tolerance and response. ,In this study,
release venlafaxine was initiated with 75 mg and increased 37.5 mg each three days up to 375 mg based on patients'
tolerance and response.
Active Comparator Drug,Active Comparator Drug
sertraline group,Extended-
release venlafaxine
Sponsors
Ahvaz Jundishapur University of Medical Sciences
Ahvaz Jundishapur University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Male or female subjects older than 18 years; Fulfilled DSM IV-TR criteria for major depressive disorder; Baseline score ≧18 on the HDRS-17; no history of antidepressant treatment during current three months.
Exclusion criteria
Exclusion criteria: Patients who have serious health problems including liver or kidney disease; axis I and II comorbidity; suicidal or killing thoughts; pregnancy; drug hypersensitivity to SSRI or SNRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| depression severity week 0, 2 and 4 during intervention the Hamilton Depression Inventory score ( HDRS-17) | — |
Secondary
| Measure | Time frame |
|---|---|
| the side effects of Sertraline and Extended-release venlafaxine week 0, 2 and 4 according to history and physical examination | — |
Countries
Iran
Contacts
Public ContactAmirali Sadegh
Ahvaz Jundishapur University of Medical Sciences
Outcome results
None listed