Inhibitory Effect of Phlai Capsule on Skin Test Response among Allergic Rhinitis Patients: a randomized, three way crossover study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20160510001

Enrollment

Unknown

Registered

2016-05-10

Start date

2015-01-01

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

&#45

Interventions

Patients were recieved oral 200 mg Phali capsules (8 capsules). Inhibition of wheal and flare response to skin prick test to histamine and aeroallergen were measured at 1&#44

12 and 24 hours after doses,Wash out of 1 week period Patients were recieved oral 100 mg Phali capsules (4 capsules). Inhibition of wheal and flare response to skin prick test to histamine and aeroal

12 and 24 hours after doses,Wash out of 1 week period Patients were recieved 1 tablet of loratidine. Inhibition of wheal and flare response to skin prick test to histamine and aeroallergen were measu

12 and 24 hours after doses

Active Comparator Drug,Active Comparator Drug,Active Comparator Drug

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: - The patients were diagnosed allergic rhinitis or allergic rhinitis with controlled asthma - Positive skin prick test to aeroallergen (wheal diameter â‰¥ 3 mm larger than the negative control with a flare) - Volunteers could be wash out antihistamine 1 week before study and during study.

Exclusion criteria

Exclusion criteria: -Any of the following underlying conditions known ; Chronic lung disease, heart disease, chronic and acute kidney diseases, liver disease - Immunotherapy treatment -Uncontrolled asthma -History of allergy to investigational drug - upper respiratory tract infection -Subject unwilling and unable to comply with the protocol

Design outcomes

Primary

Measure	Time frame
wheal and flare response to skin prick test after recieved Phlai capsule At 1, 2, 3, 4, 6, 8, 12 and 24 hours after doses. Measure by INSIZE Digital vernier Caliper	—

Secondary

Measure	Time frame
Dose comparison the effect of Phlai and comparison with loratadine on wheal size At 1, 2, 3, 4, 6, 8, 12 and 24 hours after each doses. Friedman test for non-parametric analysis	—

Countries

Thailand

Contacts

Public ContactOrapan Poachanukoon

Faculty of medicine, Thammasat University

orapanpoachankpon@gmail.com66819316781

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026

Inhibitory Effect of Phlai Capsule on Skin Test Response among Allergic Rhinitis Patients: a randomized&#44; three way crossover study