Comparison of moisturizer containing 5% urea, natural moisturizing factors, ceramide, and glyceryl glucoside with 5% urea lotion for the treatment of xerosis in children with chronic kidney disease

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20160419003

Enrollment

Unknown

Registered

2016-04-19

Start date

2012-12-19

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

xerosis chronic kidney disease xerosis&#44

Interventions

Urea is a natural moisturizing factor and improves skin barrier function. Urea at a concentration of 5% to 10% is effective in patients with atopic dermatitis&#44

and 5% urea cream can prevent relapse of atopic dermatitis (AD).6 Glyceryl glucoside (GG) can penetrate the epidermis and increase aquaporin (AQP) 3 mRNA levels&#44

as well as improve skin hydration and barrier function in adults. Treatment of xerosis with topical GG&#44

natural moisturizing factors (NMFs)&#44

and ceramide increase skin hydration and barrier function in adults. There are no reports on the safety of urea&#45

containing lotion in children with chronic kidney disease.,Urea is a natural moisturizing factor and improves skin barrier function. Urea at a concentration of 5% to 10% is effective in patients with

and 5% urea cream can prevent relapse of atopic dermatitis (AD).

Experimental Drug,Active Comparator Drug

5% urea&#44

natural moisturizing factors&#44

ceramide&#44

and glyceryl glucoside ,5% urea lotion

Eligibility

Sex/Gender

All

Age

0 Years to 18 Years

Inclusion criteria

Inclusion criteria: children with the clinical diagnosis of xerosis in stable chronic kidney disease at the Department of Pediatrics, King Chulalongkorn Memorial Hospital

Exclusion criteria

Exclusion criteria: Patients who had any treatment within 2 weeks or other skin lesions, such as infection, eczema or acute renal failure

Design outcomes

Primary

Measure	Time frame
skin hydration baseline and after treatment corneometry	—

Secondary

Measure	Time frame
transepidermal water loss baseline and after treatment TEWAmeter	—

Countries

Thailand

Contacts

Public ContactSiriwan Wananukul

Department of Pediatrics, Faculty of Medicine, Chulalongkorn Univeristy

siriwanwananukul@yahoo.com022564951

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Comparison of moisturizer containing 5% urea&#44; natural moisturizing factors&#44; ceramide&#44; and glyceryl glucoside with 5% urea lotion for the treatment of xerosis in children with chronic kidney disease