Data on the efï¬cacy of topical antiseptics for prevention of culture contamination in neonates have been very limited. 8 Therefore,
Conditions
Interventions
Chlorhexidine gluconate is an alternative skin antiseptic,
which has been reported as being superior to povidone iodine.CHG has a broad-
spectrum bactericidal activity with a rapid onset of action by bacterial cell wall disruption. Meta-
analyses have also shown that CHG
is more effective in skin disinfection than PI in prevention
of central venous catheter–related infection. Therefore,
the
Centers for Disease Control and Prevention has recom-
mended CHG as a topical antiseptic for adults and infants
greater than 2 months of age.,10% povidone iodine are generally used to clean the
patients’ skin before taking blood. PI,
has a bactericidal action by diffusion through the bacterial cell wall and inhibition of intracellular protein and nucleic acid synthesis,
and its onset of action takes longer
than that of CHG.
Experimental Drug,Experimental Drug
Chlorhexidine group (CHG),Povidone iodine group (PI)
Sponsors
Thammasat University
Eligibility
Sex/Gender
All
Age
0 Years to 1 Months
Inclusion criteria
Inclusion criteria: Neonates with birth weight of at least 1,500 g who required blood culture were included. Eligible infants were then ran- domly allocated into either the PI group or the CHG group.
Exclusion criteria
Exclusion criteria: - patients who has history of antiseptics allegy or has skin infection at puncture site - patients who uneligible
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| efficay none contamination rate | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse effects 2 days after use antiseptics observation | — |
Countries
Thailand
Contacts
Public ContactPimprae Pengpis
Unaffiliated
Outcome results
None listed