Obstructive sleep apnea Airway inflammation
Conditions
Interventions
Experimental Device,No Intervention No treatment
Sponsors
Faculty of Medicine, Khon Kaen University
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Twenty-four patients whose age was between 30 to 70 years old volunteered to participate in the study. Patients were treated with CPAP while sleeping at night for at least five hours per night for at least five days per week for three consecutive months. Patients were diagnosed with OSA by medical specialists using polysomnography (PSG) within the month preceding the start of the study. Patients included in this study had an arousal index (AI) of at least 15/h and no history of cardiovascular disease (e.g. coronary heart disease and myocardial infarction).
Exclusion criteria
Exclusion criteria: Patients with a history of autoimmune conditions or symptoms of respiratory tract infection in the six weeks prior to the study, history of sleep apnea treatment with CPAP or oral devices, tracheostomy, or use of oxygen therapy at home were excluded. Study subjects with history of other diseases associated with high FeNO (e.g. viral respiratory tract infections, systemic lupus erythematosis, liver cirrhosis, acute lung allograft rejection, and post-transplant bronchiolitis obliterans) or history of other diseases associated with low FeNO (i.e. cystic fibrosis, HIV infection and pulmonary hypertension) were excluded as well.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| airway inflammation 06/10/2014 to 26/10/2015 FeNO | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxidative stress 06/10/2014 to 26/10/2015 MDA | — |
Countries
Thailand
Contacts
Public ContactWilaiwan Khrisanapant
Khon Kaen University
Outcome results
None listed