comparition of the effect of intravenus infusion of dexmedethomidin with labetalol on blood loss during endoscopic sinus surgery

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20160404003

Enrollment

Unknown

Registered

2016-04-04

Start date

2014-07-23

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

blood loss during endoscopic sinus surgery dexmedethomidin &#44

Interventions

1 Î¼g/kg Loading Dose and then infusion of dexmedetomodine Î¼g/kg/hr 0.4 â€“ 0.8.,Labetalol Loading Dose 0.25 mg/kg and then labetalol 20&#45

60 mg/h .

Experimental Drug,Experimental Drug

dexmedethomidin,Labetalol

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: patients aging 20-50 years with ASA Class 1 or 2 that scheduled for elective endoscopic sinus surgery.

Exclusion criteria

Exclusion criteria: patients with recurrent sinus surgery, hypertension,coronary artery diseases and renal,hepatic or cerebral insufficiency and patients with coagulopathies or receiving drugs influencing blood coagulation.

Design outcomes

Primary

Measure	Time frame
bleeding every 15 min from start of surgery visual,bleeding every 15 min from start of surgery visual	—

Secondary

Measure	Time frame
systolic blood pressure before induction - after induction - every 15min until end of surgery 5-10min a Anesthesia monitoring,diastolic blood pressure before induction - after induction - every 15min until end of surgery 5-10min a Anesthesia monitoring	—

Countries

iran

Contacts

Public Contactmohammad hossein jarahzadeh

shahid sadoughi university of medical sciences

vaziribozorg@ssu.ac.ir00989131529543

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026