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BILATERAL COMPARISON OF LIQUID PARAFFIN AND CREAM BASE ON TRANSEPIDERMAL WATER LOSS AMONG PSORIASIS PATIENTS: A RANDOMIZED TRIAL

Efficacy of moisturizers on Transepidermal water loss in psoriasis patients: an evaluator-blinded, bilateral comparison, prospective, randomized, open-labeled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20160404002
Enrollment
Unknown
Registered
2016-04-04
Start date
2015-07-18
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psoriasis is a common chronic inflammatory disease. Psoriasis patients experience pain&#44

Interventions

randomly selected to have the substances applied on normal skin and psoriasis lesions twice daily with LP on left side or right side.,randomly selected to have the substances applied on normal skin a
Experimental Other,Experimental Other
liquid paraffin,cream base

Sponsors

Institute of Dermatology
Lead Sponsor
&#45
Collaborator

Eligibility

Sex/Gender
All
Age
0 Years to 0 Years

Inclusion criteria

Inclusion criteria: The eligible participants were patients who were diagnosed with plaque psoriasis and had mild severity of psoriasis with PASI score less than 10 and had the following characteristics: 3.2.1.1 Were male or female. 3.2.1.2 Aged of 18 years or above. 3.2.1.3 Willing to be in the study and gave written informed consent.

Exclusion criteria

Exclusion criteria: The participants who had the following characteristics were excluded from the study: 3.2.2.1 In condition that could not take care of themselves. 3.2.2.2 Had chronic diseases such as liver or kidney diseases. 3.2.2.3 Had history of allergy to liquid paraffin or cream base.

Design outcomes

Primary

MeasureTime frame
Transepidermal water loss (TEWL) at 4-week baseline, at 60 minutes after applying the agents and at the 4th week study was conducted among 100 participants with mild plaque type psoriasis [Psoriasis Area and Sever

Secondary

MeasureTime frame
Skin hydration, PASI Score, EQ-5D-5L baseline, at 60 minutes after applying the agents and at the 4th week study was conducted among 100 participants with mild plaque type psoriasis [Psoriasis Area and Sever

Countries

Thailand

Contacts

Public ContactPravit Asawanonda

Department of Dermatology

fibrosis@gmail.com02-2564000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026