nausea vomiting Breast cancer,
Conditions
Interventions
2.7 gr Persumac(prepared based on Iranian traditional medicine formulations) in black sachet,
three time,
30 min. before meal with one glass cold water ,2.7 gr lactose in black sachet,
30 min. before meal with one glass cold water
Experimental Drug,Placebo Comparator Drug
Persumac,lactose
Sponsors
Vice of research, Mashhad University of Medical Sciences
Vice of research,
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 0 Years
Inclusion criteria
Inclusion criteria: Female, Definitive diagnosis of breast cancer by oncologists and a pathology report by pathologists, Age>18 years, History of chemotherapy induced nausea and vomiting resistant to conventional therapy, Normal tests for CBC, urea, creatinine, Alt, Ast, Bilirubin, FBS, Na, K, Have at least three sessions of chemotherapy ahead.
Exclusion criteria
Exclusion criteria: Total or upper abdominal radiation therapy along with chemotherapy- Taking anticoagulants, Use of other drugs/therapy for nausea and vomiting that not prescribed in this study, Hypersensitivity to Sumac or Bunium Persicum, Use of sumac and Bunium Persicum in seven days prior to the intervention, Diseases of the digestive system, Diseases that may associate with nausea and vomiting (such as hypertension, liver failure and kidney, digestive problems), Milk allergy, Losing of two consecutive or three intermittent doses of intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of nausea in acute phase first 24 hour after intervention number,Frequency of nausea in delayed phase 24 hour to fifth day after intervention number,Frequency of vomiting in acute phase first 24 hour after intervention number,Frequency of vomiting in delayed phase 24 hour to fifth day after intervention number,severity of nausea in acute phase first 24 hour after intervention number,severity of nausea in delayed phase 24 hour to fifth day after intervention number,severity of vomiting in acute phase first 24 hour after intervention number,severity of vomiting in delayed phase 24 hour to fifth day after intervention number | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of nausea in delayed phase Day 2-5 of intervention number,Frequency of vomiting in delayed phase Day 2-5 of intervention number,severity of nausea in delayed phase Day 2-5 of intervention number,severity of vomiting in delayed phase Day 2-5 of intervention number | — |
Contacts
Public ContactSadegh Shokri
School of Persian and Complementary medicine
Outcome results
None listed