Dry eye transdermal androgen,
Conditions
Interventions
The androgen group will receive the androgel 50mg 1 sachet for applying at the lower abdomen alternating day for 4weeks and the artificial eye drop for instill both eyes as needs.
androgen group
Sponsors
Faculty of medicine
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: -The menopause women or women who underwent bilateral salpingo-oophorectomy -The men who have the low level of serum testosterone (normal level 1.93-7.40 ng/mL) -The volunteers who have the sign and symptom of dry eye disease such as Ocular surface disease index score (OSDI) more than 12, fluorescein tear break up time (TBUT) less than 10 sec., Schirmer test I less than 10 mm. or positive corneal fluorescein staining - No previous androgen replacement therapy within 3months
Exclusion criteria
Exclusion criteria: -History of androgen hypersensitivity or ethanol hypersensitivity - History of breast cancer - History of prostate cancer - History of skin disease or skin inflammation at apply area -Can not follow up 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular surface and dry eye at week4 Ocular surface disease index score, VA, corneal fluorescein staining, TBUT, Schirmer test I | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum testosterone level and and sex-hormone binding globulin (SHBG) level at week4 Serum testosterone and and sex-hormone binding globulin (SHBG) | — |
Countries
Thailand
Contacts
Public ContactDr.Sumet Supalaset
Department of ophthalmology, Chiang Mai University
Outcome results
None listed