Weight-based dosing of ondansetron administered before spinal anesthesia to reduce hypotension in cesarean section: A randomized controlled superiority trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20160323001

Enrollment

228

Registered

2016-03-23

Start date

2016-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension Ondansetron, Hypotension, Spinal anesthesia, Cesarean section

Interventions

Given Normal saline total 4 ml before spinal block,given ondansetron 0.05 mg/Kg before spinal block,given ondansetron 0.1 mg/Kg before spinal block

Experimental Drug,Experimental Drug,Experimental Drug

Normal saline,Ondansetron 0.05 mg/Kg,ondansetron 0.1 mg/Kg

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Pregnancy ASA classification I-II Gestational age 37-42 weeks Spinal anesthesia Singleton pregnancy no labor pain normal EKG

Exclusion criteria

Exclusion criteria: Refused to spinal block Hypertensive disorder of pregnancy ondansetron allergy Heart disease Coagulation abnormal Morbid obesity Placenta previa or totalis

Design outcomes

Primary

Measure	Time frame
Incidence of hypotension after end of interventions incidence of hypotension	—

Secondary

Measure	Time frame
Complication of ondansetron after end of intervention itching, burn, apgar score,Complication of ondansetron after end of intervention itching, burn, apgar score	—

Countries

Thailand

Contacts

Public ContactThitikan Kunapaisal

Unaffiliated

nest_lala@hotmail.co.th0805481132

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026