Motor power grade ≤ 2 Medical research council for first attack At least 2-
Conditions
Interventions
intravenous methylprednisolone 1 gram daily for 5-
7 days,
if no improvement of neurological outcome,
add on plasma exchange is performed,Plasma exchange with albumin 1 plasma volume/cycle for 5 cycles (alternating day)
intravenous methylprednisolone,plasma exchange
Sponsors
none
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Diagnosis of neuromyelitis optica/neruomyelitis optica spectrum disorder Admit at siriraj hospital during 2016-2017 Diagnosis of acute severe attack of NMO within 30 days Severe attack was defined at least one of the following Motor power grade ≤ 2 Medical research council for first attack At least 2-point worsening in 1 of the pyramidal of functional system score (FSS) compared to last visit At least 1-point worsening in EDSS score compared to last visit if previous EDSS score is 5.5 or more Visual acuity ≤ 20/200 one eye Glascow coma scale < 6 Hemodynamic instability or respiratory failure
Exclusion criteria
Exclusion criteria: Previous treatment with intravenous steroid Time to next relapse shorter than 90 days Serious / uncontrolled infection Hemodynamic unstable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| improvement of neurological outcome at discharge and 6 months Expended disability status scale | — |
Secondary
| Measure | Time frame |
|---|---|
| side effect of treatment during the admission, 1 month, 3 months and 3 months side effect | — |
Countries
Thailand
Contacts
Public ContactTayanan Srisupaolan
neurology deparment
Outcome results
None listed