Targeted-Volume Non-Invasive Ventilation in Post Planned Extubation in Medical Intensive Care Unit Patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20160310001

Enrollment

Unknown

Registered

2016-03-10

Start date

2016-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory failure Reintubation rate Mortality rate Acute respiratory failure Reintubation rate Targetted volume non invasive ventilation

Interventions

Targetted&#45

volume non&#45

invasive ventilation will be applied to post planned extubation patient immediately after extubation. Target tidal volume is 6&#45

8 ml/kg ideal body weight. IPAPmax is 26 cmH2O unless not achieve target tidal volume in morbid obesity&#44

30 cmH2O is preferred. IPAPmin is EPAP+4 cmH2O. EPAP start at 4 cmH2O then titrate to keep SpO2 >90%. Backup rate is set at 12 bpm. Inspired time is 1 sec.,Oxygen mask without reservior bag is applied

Experimental Device,Active Comparator Device

invasive ventilation,Standard care

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Intubation due to Acute respiratory failure (PaO2 50 mmHg with pH <7.30) Mechanical ventilation longer than 48 hours Readiness to extubation No history of extubation failure (in this admission) No facial anomaly, No unable to fit mask Informed consent

Exclusion criteria

Exclusion criteria: Post tracheostomy Patient with upper airway obstruction immediate after extubation (develop inspiratory stridor) Cause of respiratory failure from COPD with acute exacerbation or cardiogenic pulmonary edema Claustrophobia Patient incooperative

Design outcomes

Primary

Measure	Time frame
Reintubation rate 48 hours after extubation incidence rate	—

Secondary

Measure	Time frame
mortality rate, incidence of pneumonia 28 days after extubation Incidence rate	—

Countries

Thailand

Contacts

Public ContactVorawut Thanthitaweewat

Chulalongkorn university

v.thanthitaweewat@gmail.com0897638538

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Targeted&#45;Volume Non&#45;Invasive Ventilation in Post Planned Extubation in Medical Intensive Care Unit Patients