Patients scheduled for elective hepatectomy due to any reason at Department of surgery ,
Conditions
Interventions
The Partial infrahepatic IVC calmping group ,
Infrahepatic IVC will be partially clamped just before starting hepatic resetion without any anesthiological technique to reduce CVP . The CVP will be monitored without controlling ,The None infrahe
Venodilators administration(Nitroglycerine) and Diuretics administration,
aiming to keep CVP level below 5 cmH2O
Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery
Partial infrahepatic IVC clamping,None infrahepatic IVC clamping
Sponsors
Research Fund from Faculty of madicine , Chiang Mai University
Research Fund from Faculty of madicine ,
Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: -Age ≥ 18 years -Elective hepatic resection due to any reason -American Society of Anesthesiologists (ASA) score I to III -Written informed consent
Exclusion criteria
Exclusion criteria: •Presence of medical conditions putting the individual patient at increased risk for not tolerating hepatic resection - Liver cirrhosis (Child-Pugh B or C) - Coagulopathy •Technical impossibility of hepatic resection •Presence of medical conditions putting the individual patient at increased risk of not tolerating at least one of this trial's study interventions: - Severe heart disease (e.g. severe coronary artery disease requiring intervention, cardiac insufficiency NYHA stage IV) - Pulmonary hypertension - Renal insufficiency (serum creatinine > 2 mg/dl or > 177 μmol/l; conversion factor 88.4 or requiring dialysis) - Uncorrected electrolyte imbalance •Atrial fibrillation •For female patients: pregnancy or lactation •Participation in other clinical trials or observation period of competing trials interfering with the endpoints of this trial •Suspected lack of compliance •Impaired mental status or language problems •Refusal to take part in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra-operative blood loss Intraoperative period ml/The amount of blood loss is measured from the amount of blood collected in the suction containers | — |
Secondary
| Measure | Time frame |
|---|---|
| CVP Intraoperative period cmH2O / The CVP wasmeasure via Central venous catherter by anesthesiologist,Intraoperative hemodynamic status-Heart rate and MAP Intraoperative period beats per min and mmHg,Operation time Intraoperative period minute,Intraoperative blood and blood component transfusion Intraoperative period unit,Post operative blood and blood component transfusion Postoperative period unit,Postoperative hospitalization Postoperative period until the patient was discharged from hospital days,Complication Intraoperativeand post operative period The complication will be recorded both intraoperation and postoperation,such as Pulmonary air emboli | — |
Countries
Thailand
Contacts
Public ContactKarnpichamonch Suwannikom
Department of surgery , Maharaj Nakorn Chiang Mai hospital , Faculty of medicine , Chiang Mai univer
Outcome results
None listed