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Effect of topical application of Nigella sativa oil and oral acetaminophen on pain in elderly with knee Osteoarthritis in Clinical Trials

Effect of topical application of Nigella sativa oil and oral acetaminophen on pain in elderly with knee Osteoarthritis in Clinical Trials

Status
Recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20160125003
Enrollment
40
Registered
2016-01-25
Start date
2014-01-19
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Background: There is limited evidence to support the Nigella sativa&#39

Interventions

None listed

Sponsors

Sabzevar University Medical Sc
Lead Sponsor
Sabzevar University Medical Sc
Collaborator

Eligibility

Sex/Gender
All
Age
65 Years to 85 Years

Inclusion criteria

Inclusion criteria: Age over 65 years, diagnosis of knee osteoarthritis according to American College Rheumatology diagnostic criteria including: 1) knee pain on most days of last month, 2) crepitus (joint sound in active motion). 3) Morning stiffness less than 30 minutes. 4) aged 45 to 60 years, 5) inflation in the examination of the knee bone, respectively (13), knee osteoarthritis confirmed by a physician, and the use of radiography, knee pain in the past 24 hours, so that the average linear measure - visual pain (VAS: Visual Analogue Score) is between 4-7 cm,

Exclusion criteria

Exclusion criteria: lack of inflammatory diseases, metabolic disorders (diabetes), cancer or malignant diseases, symptoms or a history of liver or kidney failure, treatment with oral corticosteroids in the past 4 weeks or injection in the last 6 months, no fever, lack of sensitivity and allergy Nigella sativa oil, not wanting to continue to participate in the study, supplementation with vitamin - mineral or other nutritional supplements painkillers were the exit standards of the study.

Design outcomes

Primary

MeasureTime frame
Effect of topical application of Nigella sativa oil and oral 2015 Pain was determined using visual scale (VAS)

Secondary

MeasureTime frame
Effect of topical application of Nigella sativa oil and oral 2015 Pain was determined using visual scale (VAS)

Countries

IRAN

Contacts

Public Contactakram kooshki

sabzevar university medical sci

akooshki.nutr@yahoo.com+989159701470

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026