Effect of intermittent very-low-calorie diet on glycemic control and cardiovascular risk factors in obese patients with type 2 diabetes mellitus

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20160118001

Enrollment

Registered

2016-01-18

Start date

2016-06-08

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes mellitus type 2 Obesity Dietary intervention intermittent very low calorie diet type 2 diabetes mellitus Obesity Cardiovascular risk factors Quality of life

Interventions

intermittent very low calorie diet ( 600 kcal/day) 5 days a week for 2 weeks then 2 days per week for 18 weeks.,Nutritional Education

Experimental Other,No Intervention No treatment

Intermittent very low calorie diet,Control group

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Personnel of King Chulalongkorn Memorial Hospital with type 2 diabetes 2. Age 20-60 years 3. Glycated hemoglobin level > 6.5% 4. Diabetes duration 23 kg/m2

Exclusion criteria

Exclusion criteria: 1. Patients were treated with TZD, GLP-1 agonist or insulin treatment. 2. Serum creatinine > 1.5 mg/dL 3. Serum ALT > 2.5 folds above UNL 4. Serum C-peptide < 1 nmol/L

Design outcomes

Primary

Measure	Time frame
Diabetes remission 0, 2, 10, 20 week of study 75 gm OGTT	—

Secondary

Measure	Time frame
Cardiovascular risk factors 0, 2, 10, 20 weeks of study Blood levels of inflammatory cytokines, body composition	—

Countries

Thailand

Contacts

Public ContactMongkontida Umphonsathien

Chulalongkorn University

muijai@hotmail.com66817217762

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Effect of intermittent very&#45;low&#45;calorie diet on glycemic control and cardiovascular risk factors in obese patients with type 2 diabetes mellitus