apnea of prematurity apnea of prematurity aminophylline
Conditions
Interventions
Aminophylline dose by using standard dose,Aminophylline dose calculated by using pharmacokinetics dosing equation
Experimental Other,Experimental Other
standard aminophylline dosage,pharmacokinetics dosing equation
Sponsors
Faculty of Medicine Siriraj Hospital
Eligibility
Sex/Gender
All
Age
1 Days to No maximum
Inclusion criteria
Inclusion criteria: 1. Preterm infant less than or equal to 34 weeks gestation 2. Attending physicians plan to start aminophylline indicated by 2.1 apnea of prematurity 2.2 prophylaxis for apnea of prematurity 3. Parents understand Thai language 4. Informed consent obtained
Exclusion criteria
Exclusion criteria: 1. Infants with congenital neurological anomalies or chromosomal abnormality 2. Infants whom apnea is due to other causes, e.g. sepsis 3. infants who are receiving drugs which affect aminophylline level:- phenobarbital, phenytoin, erythromycin and propranolol 4. Infants who received aminophylline within 7 days prior to the study 5. infants with renal insufficiency diagnosed by 5.1 urine output less than 1 ml/kg/hr within 12 hours prior to the study 5.2 creatinine level more than or equal to 1.6 mg/dL for infants less than or equal to 27 weeks gestation 5.3 creatinine level more than or equal to 1.1 mg/dL for infants 28-29 weeks gestation 5.4 creatinine level more than or equal to 1 mg/dL for infants 30-32 weeks gestation 6. Infants who have total bilirubin > 2 mg/dL or SGOT > 140 IU/L or SGPT > 50 IU/L
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| aminophylline level before the 8th maintenance dose of aminophylline blood aminophylline level within therapeutic range | — |
Secondary
| Measure | Time frame |
|---|---|
| side effect of aminophylline throughout the study number of side effects of amniphylline | — |
Countries
Thailand
Contacts
Public ContactSopapan Ngerncham
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed