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Optimal dose of protamine for heparin reversal in open heart surgery

Optimal dose of protamine for heparin reversal in cardiopulmonary bypass surgical patient

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20151118005
Enrollment
Unknown
Registered
2015-11-18
Start date
2015-11-17
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult patient underwent cardiopulmonary bypass surgery cardiopulmonary bypass&#44

Interventions

Protamine was used equally the initial dose of heparin,Protamine was used equally the initial and additional doses of heparin,Protamine was used equally the total dose of heparin
Treatment,Treatment,Treatment
Protamine initial dose,Protamine addition dose,Protamine total dose

Sponsors

Faculty of Medicine, Prince of Songkla University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Underwent cardipoulmonary bypass surgery

Exclusion criteria

Exclusion criteria: 1.Renal failure 2.Liver failure 3.Redo surgery 4.Endocarditis 5.Thoracic aortic aneurysm 6.Cyanotic heart disease 7.Preoperative use anticoagulant 8.Use intraoperative or postoperative of intra-aortic balloon pump (IABP) or extracorporeal membrane oxygenation (ECMO) 9.Heparin resistance 10.Intraoperative death 11.Use total circulatory arrest technique 12. Incomplete data

Design outcomes

Primary

MeasureTime frame
Protamine dose intraoperative and postoperative mg—

Secondary

MeasureTime frame
Activated clotting time intraoperative and postoperative second—

Countries

Thailand

Contacts

Public ContactPanthila Rujirojindakul

Prince of Songkla University

rpanthi@medicine.psu.ac.th066 7445 1651

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026