Traumatic optic neuropathy Traumatic optic neuropathy
Conditions
Interventions
Depot medroxyprogesterone acetate (DMPA) 1 mg/kg. intramuscular injection every 12 hrs. for 5 days,Review steroid treatment in the past,Observation
Experimental Drug,No Intervention Drug,No Intervention No treatment
Progesterone group,Steriod group,Observation group
Sponsors
Phramongkutkloa college of medicine
Phramongkutkloa college of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Male or female patient, aged 18-65 years old. 2. Diagnosed with indirect traumatic optic neuropathy within 7 days 3. No other ocular or visual pathway effecting visual function
Exclusion criteria
Exclusion criteria: 1. Low level of consciousness and unable to evaluated visual acuity 2. Other system injury such as cardiovascular, pulmonary injury 3. Progesterone administration within 30 days 4. Contraindicated to progesterone as following 1) Pregnancy or lactation 2) Abnormal vaginal bleeding 3) Breast mass or history of breast cancer 4) Uncontrolled blood pressure >180/110 mmHg. 5) Diabetes mellitus with complications 6) Diagnosed or history of ischemic heart disease 7) Occlusive vascular diseases 8) Active viral hepatitis, cirrhosis, liver cancer 9) Coagulopathy, deep vein thrombosis, pulmonary embolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual acuity Baseline, 1wk, 1mo, 3mo ETDRS chart | — |
Secondary
| Measure | Time frame |
|---|---|
| Color vision, visual field testing Baseline, 1wk, 1mo, 3mo Ishihara test, Humphrey automated perimetry | — |
Countries
Thailand
Contacts
Public ContactSaran Jiranansiri
Phramongkutklao hospital
Outcome results
None listed