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Zinc supplement for Dengue fever

A randomized controlled trial of zinc supplementation for regulation severity of dengue viral infection in children

Status
Recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20151110001
Enrollment
Unknown
Registered
2015-11-10
Start date
2016-01-01
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dengue cases as per WHO classification (2009) Child&#44

Interventions

Children in treatment group will be given chelated zinc in form of zinc bis&#45
glycinate (15 mg elemental zinc) 3 times a day for 5 days or until convalescence of fever.,Children in placebo group will receive ORS based placebo which is prepared by the same manufacturer and is in

Sponsors

Srinakharinwirot University
Lead Sponsor
Srinakharinwirot University
Collaborator

Eligibility

Sex/Gender
All
Age
1 Years to 15 Years

Inclusion criteria

Inclusion criteria: children with fever and 2 of the following criteria: 1) nausea, vomiting 2) rash 3) aches and pain 4) Touniquet test positive 5) Leukopenia 6) any warning sign (adbominal pain or tenderness, persistent vomiting, clinical fluid accumulation, mucosal bleeding, lethargy or restlessness, liver enlargment >2 cm, increase in HCT concurrent with rapid decrease in platelet count

Exclusion criteria

Exclusion criteria: children already taking vitamin or minerals regularly or having allergy to them will be excluded. Children with known history of chronic systemic illness will also be excluded.

Design outcomes

Primary

MeasureTime frame
recovery time at the end of study day of covalescence of fever

Secondary

MeasureTime frame
plasma zinc levels 72 hours direct mesure of plasma zinc

Countries

Thailand

Contacts

Public ContactSanguansak Rerksuppaphol

Srinakharinwirot University

sanguansak_r@hotmail.com0817231766

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026