Comparison of effectiveness among standard dose I-131 plus lithium carbonate, high dose I-131 and high dose I-131 plus lithium carbonate in rapid turnover Graves' disease patients.

Effectiveness of I-131 low dose versus high dose with or without lithium carbonate in rapid turnover Graves' disease patients:Randomized control trail study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20151023001

Enrollment

Unknown

Registered

2015-10-23

Start date

2015-04-21

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rapid turnover Graves&#39

Interventions

I&#45

131 100 microCi/gm with lithium carbonate treatment,I&#45

131 150 microCi/gm with lithium carbonate ,I&#45

131 200 microCi/gm

Active Comparator Drug,Active Comparator Drug,Active Comparator Drug

low dose I&#45

131 with lithium carbonate,high dose I&#45

131

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1.Graves'disease with rapid turnover rate of I-131 uptake (1stRAI) 2. Thyroid gland weight > 50 gm 3. Age over 18 years old

Exclusion criteria

Exclusion criteria: 1.Previous treatment with radioiodine or surgery (total thyroidectomy) 2. Pregnancy or lactation 3. Incomplete course of lithium carbonate

Design outcomes

Primary

Measure	Time frame
percentage of cure 12 months thyroid function test (FT3, FT4, TSH)	—

Secondary

Measure	Time frame
none none none	—

Countries

Thailand

Contacts

Public ContactSiwaporn Thamcharoenvipas

Division of nuclear medicine Chulalongkorn Hospital

pueng_pst@hotmail.com0805443408

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Comparison of effectiveness among standard dose I&#45;131 plus lithium carbonate&#44; high dose I&#45;131 and high dose I&#45;131 plus lithium carbonate in rapid turnover Graves&#39; disease patients.