Efficacy of sublingual misoprostol with or without loading vaginal misoprostol pretreatment in second trimester medical termination of pregnancy: A randomized controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20151007001

Enrollment

106

Registered

2015-10-07

Start date

2015-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

termination of pregnancy second trimester medical termination of pregnancy

Interventions

start misoprostol 800 microgram via vaginal suppo then misoprostol 200 microgram via sublingual every 3 hr(Max dose = 5 dose) ,start misoprostol 400 microgram sublingual every 3 hr(Max dose = 5 dose)

Experimental Drug,Active Comparator Drug

sublingual misoprostol with loading vaginal misoprostol ,sublingual misoprostol without loading vaginal misoprostol

Eligibility

Sex/Gender

Female

Age

12 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Singleton pregnancy GA 14-24 week 2. obstetric condition a. maternal severe medical condition b. fetal anomaly or abnormal chromosome that nonviable c. fetal thalassemia major d. fetal death

Exclusion criteria

Exclusion criteria: 1. allergy to misoprostol 2. previous cesarean section or myomectomy

Design outcomes

Primary

Measure	Time frame
success rate at 24 and 48 hrs time after start misoprostol Chi-square test	—

Secondary

Measure	Time frame
induction to abortion time,side effect of misoprostol after abortion timing after start misoprostol , questionaire	—

Countries

thailand

Contacts

Public Contactkiattisak promwangkwa

Prapokklao Hospital

depapepe42121@gmail.com0810204385

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026