COPD with acute exacerbation High flow nasal oxygen cannula Chronic obstructive lung disease COPD Acute exacerbation Treatment outcomes
Conditions
Interventions
Nasal high flow oxygen cannula which provides constant flow about 30-
35 L/min with constant FiO2 and temperature,Standard oxygen cannula,
mask without bag or mask with bag
Active Comparator Device,Active Comparator Device
High flow oxygen cannula,Conventional oxygen therapy
Sponsors
Ratchadaphiseksomphot Endowment Fund
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age ≥40 year 2. Diagnosis of COPD 3. Acute exacerbation 4. Hypoxemia
Exclusion criteria
Exclusion criteria: 1. Acut hypercapnia 2. Need for non-invasive or invasive mechanical ventilation 3. Severe hemodynamic instability 4. Severe comorbidities (Cardiovascular, Cerebrovascular disease) 5. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Requirement for non-invasive and invasive mechanical ventilation in each group 72 hours Time to event | — |
Secondary
| Measure | Time frame |
|---|---|
| Level of partial pressure of oxygen (PaO2) in arterial blood gas 72 hours Blood puncture,Level of partial pressure of carbon dioxide (PaCO2) in arterial blood gas 72 hours Blood puncture,Change in respiratory rate (RR) 72 hours Observation,Change in dyspnea score and comfort score 72 hours Interview,Length of stay Until hospital discharge Observation | — |
Countries
Thailand
Contacts
Public ContactAmornpun Wongkarnjana
Chulalongkorn University
Outcome results
None listed