Outcomes of randomized controlled trial comparing the modified high dose omeprazole and amoxicillin triple therapy with the standard triple therapy in Helicobacter pylori eradication.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20150910001

Enrollment

170

Registered

2015-09-10

Start date

2015-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori eradication rate Modified triple therapy

Interventions

Amoxicillin 500 mg tid&#44

Clarithromycin 500 mg bid x 14 days,Omeprazole 20 mg bid&#44

Amoxicillin 1000 mg bid&#44

Clarithromycin 500 mg bid x 14 days

Experimental Drug,Active Comparator Drug

Modified triple therapy,Standard triple therapy

Omeprazole 20 mg tid&#44

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age over 18 years old 2. Positive for rapid urease test 3. Never recieve Helicobacter pylori eradication 4. Not on PPI, bismuth or antibiotic in the last month 5. Volnteer accept

Exclusion criteria

Exclusion criteria: 1. History of stomach cancer 2. Uncontrolled underlying disease 3. Pregnancy or breast feeding 4. Drugs addict 5. History of PPI, penicillin or clarithromycin allergy

Design outcomes

Primary

Measure	Time frame
Helicobacter pylori eradication rate now Chi-square test or Fisherâ€™s exact test	—

Secondary

Measure	Time frame
CYP2C19 prevalence now Chi-square test or Fisherâ€™s exact test,Clarithromycin resistance now Chi-square test or Fisherâ€™s exact test	—

Countries

Thailand

Contacts

Public ContactUaepong Limpapanasit

Fellow

uaepong@hotmail.com0818734579

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026