Patients suffered from limbal stem cell deficiency which are Stevens Johnson Syndrome Toxic Epidermal Necrolysis Chemical injury Thermal injury Idiopathic limbal stem cell deficiency Iatrogenic limbal stem cell deficiency
Conditions
Interventions
Removal of the pannus on ocular surface,
followed by amniotic membrane transplantation. The Cultivated limbal epithelium stem cell is transplanted to the affected eye.
Experimental Procedure/Surgery
Cultivated limbal epithelium stem cell transplantation
Sponsors
Government Research Budget
Eligibility
Sex/Gender
All
Age
10 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients suffered from limbal stem cell deficiency which are Stevens Johnson Syndrome Toxic Epidermal Necrolysis Chemical injury Thermal injury Idiopathic limbal stem cell deficiency Iatrogenic limbal stem cell deficiency or post surgical limbal stem cell deficiency medication induced limbal stem cell deficiency
Exclusion criteria
Exclusion criteria: 1. conditions that are contraindicated to systemic immunosuppression such as renal or hepatic insufficiency, Diabetes Mellitus 2. subjects with immunodeficiency status 3. Known allergic to medication used in this studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| success rate of transplantation 2 clinical observation | — |
Secondary
| Measure | Time frame |
|---|---|
| success rate of cultivation 1 quality of cultivated cells | — |
Countries
Thailand
Contacts
Public ContactVilavun Puangsrichareon
Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University
Outcome results
None listed