Efficacy of high-flow nasal cannula compared with Conventional oxygen therapy In emergency participants with cardiogenic pulmonary edema: a randomized controlled study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20150727001

Enrollment

128

Registered

2015-07-27

Start date

2015-09-08

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiogenic pulmonary edema diagnosed by &#45

Interventions

Conventional oxygen therapy via nasal cannula or facemask is continued. Medical staff will adjust the flow to keep oxygen saturation by pulse oximetry equal to or more than 95%&#44

or 88% &#45

92% for hypercapnic participants for 60 minutes,High flow oxygen is delivered by OptiflowTM cannula using an AirvoTM flow source (Fisher & Paykel Healthcare Ltd). The initial flow will be set at 35 L/

92% for hypercapnic participants and maintain there for 60 minutes.

Active Comparator Device,Active Comparator Device

Conventional oxygen therapy,High flow oxygen given via nasal cannula

Eligibility

Sex/Gender

All

Age

18 Years to 0 Years

Inclusion criteria

Inclusion criteria: 1. Age > 18 years old 2. Diagnosed cardiogenic pulmonary edema - History of acute dyspnea - Bilateral rales on physical examination - Signs of pulmonary congestion shown on initial chest x-ray 3. Pulse oximetry 24 times per minute

Exclusion criteria

Exclusion criteria: 1. Participants who need immediate intubation 2. Participants with acute coronary syndrome 3. Participants with depressed level of consciousness (GCS 35 times per minute or SpO2 < 90% during or after having been given standard oxygen therapy for 10 minutes 7. Participants with CKD stage V or end-stage renal disease (ESRD) 8. Participants contraindicated for HFNC 9. Participants with concomitant pneumonia

Design outcomes

Primary

Measure	Time frame
change in respiratory rate at 60 minutes physical examination	—

Secondary

Measure	Time frame
change in SpO2 at 15, 30, 60 minutes pulse oximetry,change in heart rate and blood pressure at 15, 30, 60 minutes physical examination and spygmomanometer,Dyspnea score at 15, 30, 60 minutes Visual analog scale,Comfort score at 60 minutes Visual analog scale,change in CXR within 8 hours pulmonary edema score,Adverse event rate over study period monitor patients,Requirement for any escalation to intubation and/or NIV within 24 hours monitor patients,Hospital length of stay During length of stay Review hospital record,Mortality rate within 7 days Review hospital record and telephone call	—

Measure

Time frame

change in SpO2 at 15, 30, 60 minutes pulse oximetry,change in heart rate and blood pressure at 15, 30, 60 minutes physical examination and spygmomanometer,Dyspnea score at 15, 30, 60 minutes Visual analog scale,Comfort score at 60 minutes Visual analog scale,change in CXR within 8 hours pulmonary edema score,Adverse event rate over study period monitor patients,Requirement for any escalation to intubation and/or NIV within 24 hours monitor patients,Hospital length of stay During length of stay Review hospital record,Mortality rate within 7 days Review hospital record and telephone call

—

Contacts

Public ContactTanyaporn Nakornchai

instructor

tanyaporn.ploy@gmail.com0818668565

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Efficacy of high&#45;flow nasal cannula compared with Conventional oxygen therapy In emergency participants with cardiogenic pulmonary edema: a randomized controlled study