The pilot study of plasma metabolite profile after administration of Ayurved Siriraj Herbal Recipe Ha-Rak (AVS022) in relation to platelet aggregation in individual healthy volunteer.

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20150724002

Enrollment

Unknown

Registered

2015-07-24

Start date

2015-08-24

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fever platelet aggregation complementary medicine herbal medicine platelet aggregation pharmacokinetics

Interventions

AVS0222 (300 mg/capsule) 5 capsules PO single dose

Experimental Drug

AVS022

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Age between 18-45 years 2. Body Mass Index (BMI) in the range of 18-24 kg/m2 3. determined healthy by physical examination, assessment of drug abuse, medical history, and vital signs 4. Have normal or acceptable results for Complete Blood Count (CBC), Blood Urea Nitrogen (BUN), Serum Creatinine (Cr), Aspartate Amino Transminase (AST), Alanine Amino Transminase (ALT), Fasting Blood Sugar (FBS), Cholesterol, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and Triglyceride 5. Be willing to participate and signed the informed consent form

Exclusion criteria

Exclusion criteria: 1.Has history usage of other drugs, especially which can effect platelet aggregation e.g. aspirin, clopidogrel, ticlopidine 2.Has history of allergic reactions or allergy to drug especially paracetamol or NSAIDs 3.Has history of allergy reaction or allergy to AVS022 or one of its herbal components include Capparis micracantha , Clerodendrum indicum , Ficus racemosa , Harrisonia perforata., and Tiliacora triandra 4.Is regularly caffeine consumption (more than 1 time/week) and will consume it during the study period 5.Is regularly alcohol consumption (more than 1 time/week) or drug addict 6.Is a smoker or non smoker less than 14 days before enrollment 7.Is using supplements or vitamins within 14 days before enrollment and will use any of these during the study period 8.Is participation in other clinical studies within last 30 days 9.Is a pregnant woman or woman in breast feeding period or have positive pregnancy test 10.Has blood donation within last 90 days

Design outcomes

Primary

Measure	Time frame
plasma metabolite profile 0, 0.5, 1, 1.5, 2, 3, 4, 6, 24 hours LC-MS	—

Secondary

Measure	Time frame
Percentage of platelet aggregation 0, 3, 6, 24 hours after doses Light transmission aggregometry,Correlation of plasma metabolite profile and percentage of platelet aggregation 0, 3, 6, 24 hours after doses statistical correlation	—

Countries

Thailand

Contacts

Public ContactWeerawadee Chandranipapongse

Mahidol University

weerawadee.cha@mahidol.ac.th6624195253

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

The pilot study of plasma metabolite profile after administration of Ayurved Siriraj Herbal Recipe Ha&#45;Rak (AVS022) in relation to platelet aggregation in individual healthy volunteer.